Siddiqui MM, Rais-Bahrami S, Turkbey B, George AK, Rothwax J, Shakir N et al (2015) Comparison of MR/ultrasound fusion-guided biopsy with ultrasound-guided biopsy for the diagnosis of prostate cancer. Cancer 122(6):884–892Įlkhoury FF, Felker ER, Kwan L et al (2019) Comparison of targeted vs systematic prostate biopsy in men who are biopsy naive: the prospective assessment of image registration in the diagnosis of prostate cancer (PAIREDCAP) Study. N Engl J Med 382(10):917–928įilson CP, Natarajan S, Margolis DJ et al (2016) Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: the role of systematic and targeted biopsies. Lancet Oncol 20(1):100–109Īhdoot M, Wilbur AR, Reese SE et al (2020) MRI-targeted, systematic, and combined biopsy for prostate cancer diagnosis. Rouvière O, Puech P, Renard-penna R et al (2019) Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy-naive patients (MRI-FIRST): a prospective, multicentre, paired diagnostic study. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. Vng na ti khng nhn thy c trong nguyt thc ton phn. Vng na ti c th c nhn thy khi mt na mt trng b che ph bi mt tri. Basically, the umbra is the darkest area while. Penumbra l mt loi bng ti c mt mu l nh sng. Perilesional biopsy Prostate biopsy Prostate cancer Prostatectomy Targeted biopsy. Difference Between Penumbra and Umbra Penumbra and umbra are terms pertaining to the parts of shadows. Of the 104 patients who underwent prostatectomy, GG upgrading rate for TB+OL+PL was lower compared to TB (21 vs 36%, p < 0.001) and was not significantly different compared to TB+OL+PL+DC (21 vs 19%, p = 0.500).Ī biopsy strategy incorporating both intensive sampling of the umbra and penumbra improved csPCa detection and reduced risk of GG upgrading at prostatectomy. TB+OL+PL had greater csPCa detection compared to just TB+OL (41 vs 39%, p = 0.016) and TB+PL (41 vs 37%, p < 0.001). Presentation Survey Quiz Lead-form E-Book. Recent Presentations Content Topics Updated Contents Featured Contents. OL and PL cores improved the csPCa detection rate of TB from 34 to 39% (p < 0.001) and 37% (p = 0.001) respectively. Collection of Umbra vs penumbra slideshows. OL cores detected more csPCa than PL cores (31 vs 16%, p < 0.001). Out of the 398 patients included, the median number of OL and PL cores was 5 (IQR 4-7) and 5 (IQR 3-6) respectively. The incremental csPCa detection rate (GG ≥ 2) and the rate of GG upgrading on prostatectomy as OL, PL and DC sequentially added to TB were determined. All other cores were designated as distant cores (DC). Perilesional (PL) cores were defined as adjacent cores within 10 mm of the target lesion ("penumbra") whilst overlap (OL) cores were defined as cores within the ROI itself ("umbra"). Our objective is to evaluate the clinically significant prostate cancer detection rate of overlapping and perilesional systematic biopsy cores and its impact on grade group (GG) concordance at prostatectomy.īiopsy maps of those undergoing MRI-targeted (TB) and systematic biopsy (SB) were reviewed to reclassify systematic cores.
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